Einstein International Journal Organization(EIJO)

Abstract

Curcumin, a polyphenolic compound derived from turmeric, has garnered interest for its full-size therapeutic ability, along with anti-inflammatory, antioxidant, and anticancer properties. However, its clinical efficacy is often compromised by troubles related to poor bioavailability, fast metabolism, and instability. Recent improvements in formulation era have brought about progressive shipping structures designed to decorate curcumin's pharmacological profile. This evaluate explores novel formulations inclusive of nanoparticle-primarily based structures, liposomes, self-emulsifying drug shipping structures (SEDDS), and cyclodextrin complexes. We talk their mechanisms, blessings, and effect on curcumin’s bioavailability, stability, and therapeutic effectiveness. By comparing latest research, this assessment goals to provide a comprehensive assessment of ways these improvements can overcome traditional limitations and improve curcumin-based totally treatments.

Keywords: Curcumin, Bioavailability, Nanoparticle-Based Systems, Liposomes, Self-Emulsifying Drug Delivery Systems (SEDDS), Cyclodextrin Complexes, Pharmacological Efficacy.

1. Anand, P., Kunnumakkara, A. B., Newman, R. A., & Aggarwal, B. B. (2007). Curcumin and cancer: An “old-age” disease with an “age-old” solution. Cancer Letters, 255(2), 155-165. https://doi.org/10.1016/j.canlet.2007.01.029
2. Bhawna, B., & Kaur, M. (2019). A review on curcumin and its novel formulation. Journal of Drug Delivery and Therapeutics, 9(2), 232-240. https://doi.org/10.22270/jddt.v9i2.2486
3. Khade, M.A., Gupta, M.K., Srivastava, B., Hyam, S.R., Khade, A.B. (2022). Comparative Antioxidant and Antiulcer Potential of In-house and Marketed Polyherbal Formulation. International Journal of Drug Delivery Technology. 12(4), 1861-1868. https://doi.org/10.25258/ijddt.12.4.63
4. Celia, C., & Carole, M. (2020). Liposomal curcumin for cancer therapy: Advances in delivery systems. Advanced Drug Delivery Reviews, 159, 179-194. https://doi.org/10.1016/j.addr.2020.02.002
5. Choi, M. S., Kim, M. J., & Kim, K. J. (2019). Curcumin-loaded nanoparticles: A novel approach to the treatment of chronic diseases. Nanomedicine, 14(11), 1571-1586. https://doi.org/10.2217/nnm-2019-0146
6. Dhane, K., Gupta, M., Hyam, S., Patil, A. (2023). Systemic Review on Polyherbal Formulation. International Journal of Research in Pharmacy and Chemistry. 13(1), 29-37. https://doi.org/10.33289/IJRPC.17.1.2023.13(8)
7. Cui, Y., & Li, M. (2021). Cyclodextrin-based drug delivery systems: A review of their applications in cancer therapy. Journal of Pharmaceutical Sciences, 110(1), 12-20. https://doi.org/10.1016/j.xphs.2020.08.035
8. Maratha, S., Chadha, M., Garg, V., Rao, T.S. (2023). Formulation and Estimation of Atomoxetine HCl for Buccal Drug Delivery System. European Chemical Bulletin. 12(Special Issue 4), 7793-7806.
9. Dash, A. K., & Poonam, G. (2021). Self-emulsifying drug delivery systems for enhanced oral bioavailability of curcumin: A review. Journal of Drug Delivery Science and Technology, 62, 102202. https://doi.org/10.1016/j.jddst.2021.102202
10. Garg, V., Garg, N., Saini, A.K., Tyagi, G.S. (2021). Neuro AIDS: Appearance of HIV-1 in Brain, and Its Neurological Complications of AIDS. World Journal of Pharmacy and Pharmaceutical Sciences. 10(5), 477-487.
11. Debnath, N., & Choudhury, H. (2018). Advances in nanoparticle-based delivery systems for curcumin: A review. Drug Development and Industrial Pharmacy, 44(10), 1610-1623. https://doi.org/10.1080/03639045.2018.1471188
12. Dery, M., & Gautam, M. (2020). Solid lipid nanoparticles: A versatile delivery system for curcumin. Journal of Controlled Release, 319, 210-223. https://doi.org/10.1016/j.jconrel.2020.02.045
13. Dubey, P., & Singh, N. (2021). Nanocapsules for curcumin delivery: Current status and future directions. Biotechnology Advances, 50, 107-123. https://doi.org/10.1016/j.biotechadv.2021.107659
14. Eweas, A. F., & Rania, M. (2019). Novel liposomal formulations for curcumin delivery: Efficacy and safety in preclinical models. International Journal of Nanomedicine, 14, 3509-3522. https://doi.org/10.2147/IJN.S194631
15. Farzaei, M. H., & Bahramsoltani, R. (2020). The role of nanoparticles in the delivery of curcumin and other bioactive compounds: A review. Journal of Nanobiotechnology, 18(1), 144. https://doi.org/10.1186/s12951-020-00776-1
16. Gupta, S. C., & Sung, B. (2013). Cancer drug discovery and development: Curcumin as a potential candidate. Pharmacological Research, 67(1), 48-57. https://doi.org/10.1016/j.phrs.2012.09.014
17. Gutiérrez, M., & Rodríguez-Gascón, A. (2018). Formulation and evaluation of curcumin nanoparticles: A review. Journal of Nanoparticle Research, 20(1), 10. https://doi.org/10.1007/s11051-017-4023-4
18. Han, X., & Zhang, Y. (2021). Advances in nanocarrier-based drug delivery systems for curcumin: A review. Journal of Nanoscience and Nanotechnology, 21(9), 5336-5350. https://doi.org/10.1166/jnn.2021.18942
19. Jantan, I., & Ahmad, M. (2018). Nanoparticle-based drug delivery systems for curcumin: A review of recent advances. Drug Delivery, 25(1), 235-247. https://doi.org/10.1080/10717544.2017.1394482
20. Jiang, X., & Li, L. (2020). Liposomal and nanoparticle-based delivery systems for curcumin: Current developments and future perspectives. Pharmaceutics, 12(12), 1134. https://doi.org/10.3390/pharmaceutics12121134
21. Kim, H., & Kim, H. (2019). Self-emulsifying drug delivery systems: An overview of their formulation and applications in curcumin delivery. European Journal of Pharmaceutical Sciences, 139, 105070. https://doi.org/10.1016/j.ejps.2019.105070
22. Kogan, G., & Schwartz, B. (2021). Advances in cyclodextrin-based delivery systems for curcumin. Journal of Inclusion Phenomena and Macrocyclic Chemistry, 99(1), 115-126. https://doi.org/10.1007/s10847-020-00996-7
23. Kumar, A., & Bhardwaj, V. (2019). Nanoemulsions and liposomal formulations for curcumin delivery: An updated review. Current Drug Delivery, 16(3), 223-236. https://doi.org/10.2174/1567201815666190821142334
24. Liu, Y., & Wang, Y. (2020). Cyclodextrin-based delivery systems for curcumin: Mechanisms and applications. Pharmaceuticals, 13(6), 129. https://doi.org/10.3390/ph13060129
25. Liu, Z., & Xu, J. (2018). Curcumin-loaded solid lipid nanoparticles: Preparation, characterization, and in vitro release studies. Journal of Drug Delivery Science and Technology, 45, 221-228. https://doi.org/10.1016/j.jddst.2018.06.007
26. Marzouk, M. S., & Mahmoud, H. M. (2020). Advances in the formulation and delivery of curcumin: From traditional to novel approaches. Journal of Controlled Release, 325, 418-435. https://doi.org/10.1016/j.jconrel.2020.06.015
27. Nair, A., & Kalathil, S. (2021). Enhanced bioavailability of curcumin through novel nanocarriers: A review. Nanomedicine: Nanotechnology, Biology and Medicine, 36, 102371. https://doi.org/10.1016/j.nano.2021.102371
28. Sharma, R. A., & Gescher, A. J. (2018). Curcumin formulations and their role in cancer treatment: An overview. Cancer Chemotherapy and Pharmacology, 81(1), 77-92. https://doi.org/10.1007/s00280-017-3552-5
29. Zhao, X., & Zhang, X. (2019). Advances in the formulation and delivery of curcumin: Liposomes, nanoparticles, and other innovative systems. Pharmaceutical Research, 36(6), 93. https://doi.org/10.1007/s11095-019-2636-4