Einstein International Journal Organization(EIJO)

Abstract

Background: Myocardial Infarction is a major cause of cardiovascular mortality and is associated with oxidative stress and myocardial damage. The present study evaluated the cardioprotective potential of mace from Myristica fragrans against Isoproterenol-induced myocardial infarction in rats.

Methods: Ethanolic extract of mace was administered orally (100, 200, and 300 mg/kg) to Wistar Albino Rats for 15 days. Myocardial infarction was induced using isoproterenol (85 mg/kg, s.c.) on days 14 and 15. Cardioprotective effects were evaluated using ECG changes, heart rate, cardiac biomarkers (CK-MB, LDH, troponin-I), antioxidant parameters (SOD, CAT, MDA), and histopathological analysis.

Results: Isoproterenol significantly increased cardiac biomarkers, lipid peroxidation, ST-segment elevation, and heart rate while reducing antioxidant enzymes. Pretreatment with Myristica fragrans extract significantly reversed these changes in a dose-dependent manner. The 300 mg/kg dose showed the most pronounced protection, restoring biochemical parameters and myocardial architecture near normal levels.

Conclusion: Myristica fragrans exhibits significant cardioprotective activity against isoproterenol-induced myocardial injury, likely due to its antioxidant and membrane-stabilizing properties.

Keywords : Myristica Fragrans, Mace, Cardioprotection, Isoproterenol, Myocardial Infarction, Oxidative Stress, Rats.

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