Einstein International Journal Organization(EIJO)

Abstract

Introduction: Periodontitis is characterized by a complex host parasite interaction resulting in patients exhibiting higher levels of biomarkers which causes systemic inflammatory bone destruction. Routine methods of diagnosing periodontitis include assessment of clinical and radiographic parameters. The Serum levels of biomarkers may indicate the inflammatory status of periodontitis and help in evaluation of the disease activity before and after scaling and root planning.

Aim: To compare the quantitative levels of serum Parathyroid hormone, Vitamin D3, Alkaline phosphatase, Calcium and Phosphorous before and after scaling and root planning and establishing the correlation with clinical parameters in patients of periodontitis.

Materials/Methods: 30 subjects were enrolled with written and informed consent after evaluating their periodontal status. The clinical parameters recorded at baseline were Simplified Oral hygiene index, gingival index, probing pocket depth, clinical attachment loss. Serum levels of Vitamin D3, Calcium, Phosphorous, Parathyroid hormone and Alkaline phosphatase were also recorded at baseline. The clinical parameters alongwith the serum biomarkers were reevaluated after 90 days following scaling and root planing. The results were statistically analyzed using paired t?test.

Results: After analysing the data using appropriate statistical analysis, it was observed that there was a gradual increase in the serum levels of these biomarkers with progression of periodontitis and levels were reduced considerably after scaling and root `planning except for Vitamin D3 which showed an increase in serum level.

Conclusion: Based on these results, it is concluded that the serum levels of these biomarkers can be considered for evaluating the disease progression and can be correlated with the clinical parameters of periodontitis.

Keywords: Periodontitis, Probing depths, Calcium, Phosphorous, Parathyroid, Vitamin D3, Alkaline phosphatase. 

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