Einstein International Journal Organization(EIJO)

Abstract

Introduction : Rasayana has two different ways of function in our body - preventive and curative. Prameha is a disease which is characterized by Avila Mutrata ( turbidity of urine ) and Prabhuta Mutrata ( frequency of urine ) and effects all the systems. The complement system, an important soluble component of the innate immune system, is a series of plasma enzymes and regulatory proteins. The function of the complement system includes control of inflammatory reactions and chemotaxis, clearance of immune complexes, cellular activation and antimicrobial defence. Complement C3 and C4 are the major plasma proteins of the immune system complement pathways. Though Rasayana acts in multi dimension but the effect of Naimittik Rasayana in respect to complement system has not yet been carried out in the field of  Ayurvedic research works.

Aims and Objectives : The present work has been carried out to evaluate the concept of Rasayana effect in concordance to complement system in the disease Prameha ( diabetes mellitus) along with reveal the effectiveness of Khadir (Acacia catechu Linn. ) - the Naimittik Rasayana of Prameha i.e diabetes mellitus.

Materials and Methods :  60 subjects comprising both patients of Prameha and healthy volunteers were selected for the study and divided in to two groups - group of patients of Prameha & group of healthy volunteers following inclusion and exclusion criteria. Khadir ( Acacia catechu Linn. ) was administered in the selected patients at a dose of one gram equivalent, orally, twice daily, with warm water for 90 consecutive days.

Results : The subjective and objective parameters were present in maximum number of patients. The result also reveals the significant efficacy of Khadir on relevant subjective and objective parameters with a 'p-value <0.001 in all subjective and objective parameters.

Conclusion :  This study reveals that Khadir is very much effective to encounter the subjective manifestations of the disease Prameha and it is also effective to reduce the C3 & C4 level in specific along with blood glucose level along with other parameters. The concomitant relation between complementary system and Prameha are well established in respect to Vikarvighatabhava through this study.

Keywords :     Prameha, Rasayana, Vikarvighatabhava, Complementary system, Diabetes mellitus

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